Mutations in Prion Protein Gene: Pathogenic Mechanisms in C-Terminal vs. N-Terminal Domain, a Review

Mutations in Prion Protein Gene: Pathogenic Mechanisms in C-Terminal vs. N-Terminal Domain, a Review

Inherited mutations in the Prion protein (PrP), encoded by the <i>PRNP</i> gene, have been associated with autosomal dominant neurodegenerative disorders, such as Creutzfeldt&#8722;Jacob disease (CJD), Gerstmann&#8722;Str&#228;ussler&#8722;Scheinker syndrome (GSS), and Fa...

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Bibliographic Details
Main Authors: Livia Bernardi, Amalia C. Bruni
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
Prion protein mutation (PrP mutation)
PrP N-terminal domain
PrP C-terminal domain
interdomain <i>cis</i> interaction
Proline
<i>PRNP</i> gene
dementia
Online Access:https://www.mdpi.com/1422-0067/20/14/3606

Internet

https://www.mdpi.com/1422-0067/20/14/3606

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