High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive heterotopic endochondral ossification leading to...

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Bibliographic Details
Main Authors: Serena Cappato, Laura Tonachini, Francesca Giacopelli, Mario Tirone, Luis J. V. Galietta, Martina Sormani, Anna Giovenzana, Antonello E. Spinelli, Barbara Canciani, Silvia Brunelli, Roberto Ravazzolo, Renata Bocciardi
Format: Article
Language:English
Published: The Company of Biologists 2016-06-01
Series:Disease Models & Mechanisms
Subjects:
ACVR1
Transcriptional regulation
BMP signaling pathway
FOP
Dipyridamole
High-throughput screening
Drug repositioning
Online Access:http://dmm.biologists.org/content/9/6/685

Internet

http://dmm.biologists.org/content/9/6/685

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