Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct

Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct

Abstract Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Dysfunctional Tph2 alters 5-HT biosynthesis, leading to a deficiency of 5-HT, which could have repercussions on human behavior. In the last decade, several studies have associate...

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Bibliographic Details
Main Authors: Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M. Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mora
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01634-x

Internet

https://doi.org/10.1038/s41398-021-01634-x

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