Cytisine Exerts an Anti-Epileptic Effect via α7nAChRs in a Rat Model of Temporal Lobe Epilepsy

Cytisine Exerts an Anti-Epileptic Effect via α7nAChRs in a Rat Model of Temporal Lobe Epilepsy

Background and Purpose: Temporal lobe epilepsy (TLE) is a common chronic neurological disease that is often invulnerable to anti-epileptic drugs. Increasing data have demonstrated that acetylcholine (ACh) and cholinergic neurotransmission are involved in the pathophysiology of epilepsy. Cytisine, a...

Full description

Bibliographic Details
Main Authors: Jing-jun Zheng, Teng-yue Zhang, Hong-tao Liu, Ze-xin Huang, Jing-mei Teng, Jing-xian Deng, Jia-gui Zhong, Xu Qian, Xin-wen Sheng, Ji-qiang Ding, Shu-qiao He, Xin Zhao, Wei-dong Ji, De-feng Qi, Wei Li, Mei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
cytisine
temporal lobe epilepsy
neuroprotection
synaptic remodeling
cholinergic transmission
α7nAChRs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.706225/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.706225/full

Similar Items