Dynamic profiles, biodistribution and integration evaluation after intramuscular/intravenous delivery of a novel therapeutic DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in vaccinated normal rodent

Dynamic profiles, biodistribution and integration evaluation after intramuscular/intravenous delivery of a novel therapeutic DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in vaccinated normal rodent

Abstract Background The persistence, biodistribution, and risk of integration into the host genome of any new therapeutic DNA vaccine must be established in preclinical studies. We previously developed the DNA vaccine pcDNA-CCOL2A1 encoding chicken type II collagen (CCII) for the treatment of rheuma...

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Bibliographic Details
Main Authors: Xiao Zhao, Juan Long, Fei Liang, Nan Liu, Yuying Sun, Yongzhi Xi
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Nanobiotechnology
Subjects:
Therapeutic DNA vaccine
Dynamic profiles
Biodistribution
Genomic integration
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s12951-019-0528-5

Internet

http://link.springer.com/article/10.1186/s12951-019-0528-5

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