Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes

Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes

Identifying cancer-causing mutations from sequenced cancer genomes hold much promise for targeted therapy and precision medicine. “Driver” mutations are primarily responsible for cancer progression, while “passengers” are functionally neutral. Although several computational approaches have been deve...

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Bibliographic Details
Main Authors: Shayantan Banerjee, Karthik Raman, Balaraman Ravindran
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
cancer driver mutations
context of mutations
neighborhood sequences
missense mutations
machine learning
Online Access:https://www.mdpi.com/2072-6694/13/10/2366

Internet

https://www.mdpi.com/2072-6694/13/10/2366

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