The Growth Suppressing Effects of Girinimbine on Hepg2 Involve Induction of Apoptosis and Cell Cycle Arrest

The Growth Suppressing Effects of Girinimbine on Hepg2 Involve Induction of Apoptosis and Cell Cycle Arrest

Murraya koenigii is an edible herb widely used in folk medicine. Here we report that girinimbine, a carbazole alkaloid isolated from this plant, inhibited the growth and induced apoptosis in human hepatocellular carcinoma, HepG2 cells. The MTT and LDH assay results showed that girinimbine decreased...

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Bibliographic Details
Main Authors: Tang Sook Wah, Syam Mohan, Siddig Ibrahim Abdelwahab, Suvitha Syam, Mohd. Aspollah Sukari, Ahmad Bustamam Abdul
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Molecules
Subjects:
anticancer
apoptosis
carbazole alkaloid
cell cycle arrest
girinimbine
pyranocarbazole
Online Access:http://www.mdpi.com/1420-3049/16/8/7155/

Internet

http://www.mdpi.com/1420-3049/16/8/7155/

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