Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy

Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy

Background: Mucosal mast cells (MC) are key players in IgE-mediated food allergy (FA). The evidence on the interaction between gut microbiota, MC and susceptibility to FA is contradictory.Objective: We tested the hypothesis that commensal bacteria are essential for MC migration to the gut and their...

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Bibliographic Details
Main Authors: Martin Schwarzer, Petra Hermanova, Dagmar Srutkova, Jaroslav Golias, Tomas Hudcovic, Christian Zwicker, Marek Sinkora, Johnnie Akgün, Ursula Wiedermann, Ludmila Tuckova, Hana Kozakova, Irma Schabussova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
germ-free
mouse models
food allergy
mast cells
commensal bacteria
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00205/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00205/full

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