Saikosaponin-d Inhibits the Hepatoma Cells and Enhances Chemosensitivity Through SENP5-Dependent Inhibition of Gli1 SUMOylation Under Hypoxia

Saikosaponin-d Inhibits the Hepatoma Cells and Enhances Chemosensitivity Through SENP5-Dependent Inhibition of Gli1 SUMOylation Under Hypoxia

Chemosensitivity is one of the key factors affecting the therapeutic effect on cancer, but the clinical application of corresponding drugs is rare. Hypoxia, a common feature of many solid tumors, including hepatocellular carcinoma (HCC), has been associated with resistance to chemotherapy in part th...

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Bibliographic Details
Main Authors: Chun-Yan Zhang, Zhong-Min Jiang, Xiao-Fang Ma, Yue Li, Xiao-Zhi Liu, Li-Li Li, Wen-Han Wu, Tao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
Saikosaponin-d
hepatocellular carcinoma
HSVtk/GCV
Gli1
SUMOylation
SENP5
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01039/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01039/full

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