NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation. This dual role raises the question if phenotypic abnormalities resulting from deficiency of BER factors are due to DNA damage or impaired DNA dem...

Full description

Bibliographic Details
Main Authors: Dandan Han, Lars Schomacher, Katrin M Schüle, Medhavi Mallick, Michael U Musheev, Emil Karaulanov, Laura Krebs, Annika von Seggern, Christof Niehrs
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
base excision repair
NEIL DNA glycosylases
TDG
TP53
mitochondria
neural crest
Online Access:https://elifesciences.org/articles/49044

Internet

https://elifesciences.org/articles/49044

Similar Items