Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson’s disease

Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is characterised by dopaminergic cell loss within the substantia nigra pars compacta (SNc) that leads to reduced striatal dopamine content and resulting motor deficits. Identifying new strategies to protect these cells from degeneration and retain striata...

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Bibliographic Details
Main Authors: Edward J. R. Fletcher, Lawrence D. F. Moon, Susan Duty
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Neuroscience
Subjects:
Parkinson’s disease
Chondroitinase ABC
6-Hydroxydopamine
Neuroprotection
Chondroitin sulphate proteoglycans
Online Access:https://doi.org/10.1186/s12868-019-0543-3

Internet

https://doi.org/10.1186/s12868-019-0543-3

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