Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells

Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells

Asymmetric cell division (ACD) enables the maintenance of a stem cell population while simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo multiple modes of cell division during tumor expansion and in response to therapy, yet the functional consequences of these divisi...

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Bibliographic Details
Main Authors: Masahiro Hitomi, Anastasia P. Chumakova, Daniel J. Silver, Arnon M. Knudsen, W. Dean Pontius, Stephanie Murphy, Neha Anand, Bjarne W. Kristensen, Justin D. Lathia
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-02-01
Series:JCI Insight
Subjects:
Cell biology
Stem cells
Online Access:https://doi.org/10.1172/jci.insight.130510

Internet

https://doi.org/10.1172/jci.insight.130510

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