Synergy of Iron Chelators and Therapeutic Peptide Sequences Delivered via a Magnetic Nanocarrier

Synergy of Iron Chelators and Therapeutic Peptide Sequences Delivered via a Magnetic Nanocarrier

Here, we report the synthesis, characterization, and efficacy study of Fe/Fe3O4-nanoparticles that were co-labeled with a tumor-homing and membrane-disrupting oligopeptide and the iron-chelator Dp44mT, which belongs to the group of the thiosemicarbazones. Dp44mT and the peptide sequence PLFAERL(D[KL...

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Bibliographic Details
Main Authors: Gayani S. Abayaweera, Hongwang Wang, Tej B. Shrestha, Jing Yu, Kyle Angle, Prem Thapa, Aruni P. Malalasekera, Leila Maurmann, Deryl L. Troyer, Stefan H. Bossmann
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Journal of Functional Biomaterials
Subjects:
iron/iron oxide core/shell nanoparticle
breast cancer
therapeutic peptide sequence
iron chelator
cell viability study
Online Access:http://www.mdpi.com/2079-4983/8/3/23

Internet

http://www.mdpi.com/2079-4983/8/3/23

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