NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection.

NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection.

During viral infection, tight regulation of CD8+ T-cell functions determines the outcome of the disease. Recently, others and we determined that the natural killer (NK) cells kill hyperproliferative CD8+ T cells in the context of viral infection, but molecules that are involved in shaping the regula...

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Bibliographic Details
Main Authors: Vikas Duhan, Thamer A Hamdan, Haifeng C Xu, Prashant Shinde, Hilal Bhat, Fanghui Li, Yahya Al-Matary, Dieter Häussinger, Judith Bezgovsek, Sarah-Kim Friedrich, Cornelia Hardt, Philipp A Lang, Karl S Lang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007797

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https://doi.org/10.1371/journal.ppat.1007797

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