Modulating Heterologous Pathways and Optimizing Culture Conditions for Biosynthesis of <i>trans</i>-10, <i>cis</i>-12 Conjugated Linoleic Acid in <i>Yarrowia lipolytica</i>

Modulating Heterologous Pathways and Optimizing Culture Conditions for Biosynthesis of <i>trans</i>-10, <i>cis</i>-12 Conjugated Linoleic Acid in <i>Yarrowia lipolytica</i>

A novel recombinant strain has been constructed for converting glycerol into a specific conjugated linoleic acid isomer (<i>trans</i>-10, <i>cis</i>-12 CLA) using <i>Yarrowia lipolytica</i> as host. The lipid accumulation pathway was modified for increasing lipid...

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Bibliographic Details
Main Authors: Xun Wang, Qianjun Xia, Fei Wang, Yu Zhang, Xun Li
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
conjugated linoleic acid
metabolic engineering
<i>Yarrowia lipolytica</i>
<i>Propionibacterium acnes</i> isomerase
<i>Mortierella alpine</i> Δ<sup>12</sup> desaturase
Online Access:https://www.mdpi.com/1420-3049/24/9/1753

Internet

https://www.mdpi.com/1420-3049/24/9/1753

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