A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness

Furin, a member the proprotein convertase (PC) family, processes inactive precursor proteins to functional proteins within the Golgi/trans-Golgi network secretory pathway. Furin and other PC family members (furin/PCs) activate proteins vital to proper physiological functioning, including growth fac...

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Bibliographic Details
Main Authors: Julia M. Coppola, Mahaveer S. Bhojani, Brian D. Ross, Alnawaz Rehemtulla
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800504