Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells

Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells

Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a paracrine fashion, and endogenous TMEM16A/Anoctami...

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Bibliographic Details
Main Authors:	Monica Sala-Rabanal, Zeynep Yurtsever, Colin G Nichols, Tom J Brett
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-03-01
Series:	eLife
Subjects:	ion channel regulation calcium activated chloride channel chronic inflammatory airway disease
Online Access:	https://elifesciences.org/articles/05875

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