Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells
Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a paracrine fashion, and endogenous TMEM16A/Anoctami...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/05875 |