A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology

A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology

The brains of those with Alzheimer's disease have amyloid and tau pathology; thus, mice modeling AD should have both markers. In this study, we characterize offspring from the cross of the J20 (hAPP) and rTg4510 (htau) strains (referred to as dual Tg). Behavior was assessed at both 3.5 and 7 mo...

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Bibliographic Details
Main Authors: Stephen L. P. Lippi, Meghann L. Smith, Jane M. Flinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
mouse models
amyloid
tau
Barnes Maze
Zinc
behavior
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00382/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00382/full

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