Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer’s Disease Model in Mice

Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer’s Disease Model in Mice

Sporadic Alzheimer’s disease (AD) is the most common neurodegenerative disorder with cognitive dysfunction. Remarkably, alteration in the gut microbiome and resultant insulin resistance has been shown to be connected to metabolic syndrome, the crucial risk factor for AD, and also to be implicated in...

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Bibliographic Details
Main Authors: Nesrine S. El Sayed, Esraa A. Kandil, Mamdooh H. Ghoneum
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
metabolic syndrome
insulin signaling
alzheimer's disease
PI3/Akt pathway
PFT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.666502/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.666502/full

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