Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

Perineuronal nets (PNNs) are lattice-like extracellular matrix structures composed of chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline of neural plasticity, and disruption of PNNs reactivates neural plasticity in the adult brain. We previously reported that sul...

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Bibliographic Details
Main Authors: Shinji Miyata, Hiroshi Kitagawa
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2016/1305801