Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells

Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells

Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro maturation technique for generating functional hIOs...

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Bibliographic Details
Main Authors: Kwang Bo Jung, Ohman Kwon, Mi-Ok Lee, Hana Lee, Ye Seul Son, Omer Habib, Jung-Hwa Oh, Hyun-Soo Cho, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Journal of Clinical Medicine
Subjects:
human intestinal organoid
STAT3
in vitro maturation
CRISPR/Cas9
human embryonic stem cell
Online Access:https://www.mdpi.com/2077-0383/8/7/976

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https://www.mdpi.com/2077-0383/8/7/976

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