Loss of <i>Rb1</i> Enhances Glycolytic Metabolism in <i>Kras</i>-Driven Lung Tumors In Vivo

Loss of <i>Rb1</i> Enhances Glycolytic Metabolism in <i>Kras</i>-Driven Lung Tumors In Vivo

Dysregulated metabolism is a hallmark of cancer cells and is driven in part by specific genetic alterations in various oncogenes or tumor suppressors. The retinoblastoma protein (pRb) is a tumor suppressor that canonically regulates cell cycle progression; however, recent studies have highlighted a...

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Bibliographic Details
Main Authors: Lindsey R. Conroy, Susan Dougherty, Traci Kruer, Stephanie Metcalf, Pawel Lorkiewicz, Liqing He, Xinmin Yin, Xiang Zhang, Sengodagounder Arumugam, Lyndsay E.A. Young, Ramon C. Sun, Brian F. Clem
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
<i>rb1</i>
metabolomics
glycolysis
tca anaplerosis
lung cancer
Online Access:https://www.mdpi.com/2072-6694/12/1/237

Internet

https://www.mdpi.com/2072-6694/12/1/237

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