Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia: genetic influence on dopamine transmission

Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia: genetic influence on dopamine transmission

Objective:To assess the relationship between cognitive function, a proposed schizophrenia endophenotype, and two genetic polymorphisms related to dopamine function, catechol-O-methyl transferase (COMT) Val158Met and dopamine receptor 3 (DRD3) Ser9Gly.Methods:Fifty-eight outpatients with schizophreni...

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Bibliographic Details
Main Authors: Alexandre A. Loch, Martinus T. van de Bilt, Danielle S. Bio, Carolina M. do Prado, Rafael T. de Sousa, Leandro L. Valiengo, Ricardo A. Moreno, Marcus V. Zanetti, Wagner F. Gattaz
Format: Article
Language:English
Published: Associação Brasileira de Psiquiatria (ABP) 2015-09-01
Series:Brazilian Journal of Psychiatry
Subjects:
Endophenotype
psychosis
genetics
dopamine
executive function
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000300008&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000300008&lng=en&tlng=en

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