PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers

PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers

Abstract Background Previous studies found that [18F]LSN3316612 was a promising positron emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and human volunteers. This study sought to further evaluate the suitability of [18F]LSN3316612 for human clinical research. Meth...

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Bibliographic Details
Main Authors: Jae-Hoon Lee, Jeih-San Liow, Soumen Paul, Cheryl L. Morse, Mohammad B. Haskali, Lester Manly, Sergey Shcherbinin, J. Craig Ruble, Nancy Kant, Emily C. Collins, Hugh N. Nuthall, Paolo Zanotti-Fregonara, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis
Format: Article
Language:English
Published: SpringerOpen 2020-03-01
Series:EJNMMI Research
Subjects:
O-GlcNAcase
Positron emission tomography
Tauopathy
Test-retest reliability
Neuroimaging
Online Access:http://link.springer.com/article/10.1186/s13550-020-0616-4

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http://link.springer.com/article/10.1186/s13550-020-0616-4

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