Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling

Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling

T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILC development. Constitutive activation of Notch signaling, at the common lymphoid progenitor stage, driv...

Full description

Bibliographic Details
Main Authors: Sylvestre Chea, Sandrine Schmutz, Claire Berthault, Thibaut Perchet, Maxime Petit, Odile Burlen-Defranoux, Ananda W. Goldrath, Hans-Reimer Rodewald, Ana Cumano, Rachel Golub
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471600036X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471600036X

Similar Items