Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis

Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis

We report the biochemical and structural characterisation of a beta-carbonic anhydrase (β-CA) from Trichomonas vaginalis, a unicellular parasite responsible for one of the world’s leading sexually transmitted infections, trichomoniasis. CAs are ubiquitous metalloenzymes belonging to eight evolutiona...

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Bibliographic Details
Main Authors: Linda J. Urbański, Anna Di Fiore, Latifeh Azizi, Vesa P. Hytönen, Marianne Kuuslahti, Martina Buonanno, Simona M. Monti, Andrea Angeli, Reza Zolfaghari Emameh, Claudiu T. Supuran, Giuseppina De Simone, Seppo Parkkila
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
beta carbonic anhydrase
trichomonas vaginalis
protozoan
kinetics
crystal structure
Online Access:http://dx.doi.org/10.1080/14756366.2020.1774572

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