Synthetic Chalcones with Potent Antioxidant Ability on H2O2-Induced Apoptosis in PC12 Cells

Synthetic Chalcones with Potent Antioxidant Ability on H2O2-Induced Apoptosis in PC12 Cells

Chalcone derivatives (E)-3-(4-hydroxy-3-methoxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one and (E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one (Compounds 1 and 2) have been demonstrated to be potent anti-inflammatory agents in our previous study. In light of the relationship of intracel...

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Bibliographic Details
Main Authors: Jian-Zhang Wu, Chan-Chan Cheng, Lai-Lai Shen, Zhan-Kun Wang, Shou-Biao Wu, Wu-Lan Li, Su-Hua Chen, Rong-Ping Zhou, Pei-Hong Qiu
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:International Journal of Molecular Sciences
Subjects:
chalcone derivatives
antioxidant
PC12 cells
Nrf2-ARE pathway
GCLC
HO-1
Online Access:http://www.mdpi.com/1422-0067/15/10/18525

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http://www.mdpi.com/1422-0067/15/10/18525

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