Benzyl (R)-2-(Acetylthio)Propanoate: A Promising Sulfur Isoster of (R)-Lactic Acid and Ester Precursors

Benzyl (R)-2-(Acetylthio)Propanoate: A Promising Sulfur Isoster of (R)-Lactic Acid and Ester Precursors

In this paper, an accessible chiral pool synthesis of benzyl (R)-2-(acetylthio)propanoate (acetylthiolactate), which is less odorous than the methyl or ethyl analogue, was performed through a clean SN2 displacement reaction using available AcSK with tris[2-(2-methoxyethoxy)]ethylamine (TDA-1), start...

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Bibliographic Details
Main Authors: Ryosuke Sasaki, Momoyo Kawamoto, Yoo Tanabe
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molbank
Subjects:
thiolactic ester
benzyl (S)-lactate
(R)-2-(acetylthio)propanoate
SN2 displacement
potassium thioacetate
benzyl (R)-2-sulfanylpropanoate
HPLC analysis
odorless
Online Access:http://www.mdpi.com/1422-8599/2018/3/M1010

Internet

http://www.mdpi.com/1422-8599/2018/3/M1010

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