Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates.

Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates.

Rodent studies show that neurogenesis is necessary for mediating the salutary effects of antidepressants. Nonhuman primate (NHP) studies may bridge important rodent findings to the clinical realm since NHP-depression shares significant homology with human depression and kinetics of primate neurogene...

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Main Authors: Tarique D Perera, Andrew J Dwork, Kathryn A Keegan, Lakshmi Thirumangalakudi, Cecilia M Lipira, Niamh Joyce, Christopher Lange, J Dee Higley, Gorazd Rosoklija, Rene Hen, Harold A Sackeim, Jeremy D Coplan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3078107?pdf=render

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http://europepmc.org/articles/PMC3078107?pdf=render

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