Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

Inhibiting the tyrosine kinase activity of epidermal growth factor receptor (EGFR) using small molecule tyrosine kinase inhibitors (TKIs) is often ineffective in treating cancers harboring wild-type EGFR (wt-EGFR). TKIs are known to cause dimerization of EGFR without altering its expression level. G...

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Bibliographic Details
Main Authors: Rintu Thomas, Shivangi Srivastava, Rajasekhara Reddy Katreddy, Jason Sobieski, Zhang Weihua
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
EGFR
tyrosine kinase inhibitor
dimerization
palmitoylation
kinase-independent function
resistance
Online Access:https://www.mdpi.com/1422-0067/20/10/2515

Internet

https://www.mdpi.com/1422-0067/20/10/2515

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