Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate immune response pathways. Some of the molecular mechanisms underlying these processes, however, remain unclear. This study tes...

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Bibliographic Details
Main Authors: Marisol Fernández-Ortiz, Ramy K. A. Sayed, José Fernández-Martínez, Antonia Cionfrini, Paula Aranda-Martínez, Germaine Escames, Tomás de Haro, Darío Acuña-Castroviejo
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
melatonin
mitochondria
NLRP3 inflammasome
Nrf2
heart ultrastructure
apoptosis
Online Access:https://www.mdpi.com/2076-3921/9/12/1187

Internet

https://www.mdpi.com/2076-3921/9/12/1187

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