Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway

Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway

Steroid-induced osteonecrosis of the femoral head (SONFH) is a refractory disease induced by glucocorticoids. Marrow mesenchymal stem cells (MSCs) differentiate into multiple bone matrix cells and have been used as cell-based therapies to treat ONFH. However, the osteogenesis of MSCs isolated from p...

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Bibliographic Details
Main Authors: Xiao-Jun Chen, Ying-Shan Shen, Min-Cong He, Fan Yang, Peng Yang, Feng-Xiang Pang, Wei He, Yan-ming Cao, Qiu-Shi Wei
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Polydatin
Steroid-induced osteonecrosis of the femoral head
Bone mesenchymal stem cells
BMP pathway
Wnt pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219301659

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http://www.sciencedirect.com/science/article/pii/S0753332219301659

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