Aspiration-mediated hydrogel micropatterning using rail-based open microfluidic devices for high-throughput 3D cell culture

Abstract Microfluidics offers promising methods for aligning cells in physiologically relevant configurations to recapitulate human organ functionality. Specifically, microstructures within microfluidic devices facilitate 3D cell culture by guiding hydrogel precursors containing cells. Conventional...

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Bibliographic Details
Main Authors: Dohyun Park, Jungseub Lee, Younggyun Lee, Kyungmin Son, Jin Woo Choi, William J. Jeang, Hyeri Choi, Yunchan Hwang, Ho-Young Kim, Noo Li Jeon
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99387-6