2D- and 3D-QSAR Study of Acyl Homoserine Lactone Derivatives as Potent Inhibitors of Quorum Sensor, SdiA in Salmonella typhimurium

2D- and 3D-QSAR Study of Acyl Homoserine Lactone Derivatives as Potent Inhibitors of Quorum Sensor, SdiA in Salmonella typhimurium

A series of Acyl homoserine lactone derivatives against quorum sensing (QS) enhanced transcriptional regulator SdiA of S. typhimurium were used to establish the physicochemical and structural requirements for the inhibition of QS using 2D- and 3D-QSAR methods. The QSAR model was developed by employi...

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Bibliographic Details
Main Authors: Gnanendra Shanmugam, Syed Mohamed, Jeyakumar Natarajan
Format: Article
Language:English
Published: Bulgarian Academy of Sciences 2016-12-01
Series:International Journal Bioautomation
Subjects:
Salmonella typhimurium
2D-QSAR
3D-QSAR
CoMFA
QS inhibitors
Online Access:http://www.biomed.bas.bg/bioautomation/2016/vol_20.4/files/20.4_02.pdf

Internet

http://www.biomed.bas.bg/bioautomation/2016/vol_20.4/files/20.4_02.pdf

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