Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice.

Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice.

Neurons of the paraventricular nucleus of the hypothalamus (PVN) regulate the hypothalamic- pituitary-adrenal (HPA) axis and the autonomic nervous system. Females lacking functional GABA(B) receptors because of a genetic disruption of the R1 subunit have altered cellular characteristics in and aroun...

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Bibliographic Details
Main Authors: Matthew S Stratton, Michelle Staros, Tomaz Budefeld, Brian T Searcy, Connor Nash, Chad Eitel, David Carbone, Robert J Handa, Gregor Majdic, Stuart A Tobet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4146593?pdf=render

Internet

http://europepmc.org/articles/PMC4146593?pdf=render

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