Sterol C-22 desaturase ERG5 mediates the sensitivity to antifungal azoles in Neurospora crassa and Fusarium verticillioides

Sterol C-22 desaturase ERG5 mediates the sensitivity to antifungal azoles in Neurospora crassa and Fusarium verticillioides

Antifungal azoles inhibit ergosterol biosynthesis by interfering with lanosterol 14α-demethylase. In this study, 7 upregulated and 4 downregulated ergosterol biosynthesis genes in response to ketoconazole treatment were identified in Neurospora crassa. Azole sensitivity test of knockout mutants for...

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Bibliographic Details
Main Authors: Xianyun eSun, Wenzhao eWang, Kangji eWang, Xinxu eYu, Jie eLiu, Fucai eZhou, Baogui eXie, Shaojie eLi
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Microbiology
Subjects:
Neurospora crassa
antifungal resistance
ergosterol biosynthesis
azole
Fusarium verticillioides
resistance to antifungal agents
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00127/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00127/full

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