Integrated Metagenomics and Metabolomics to Reveal the Effects of Policosanol on Modulating the Gut Microbiota and Lipid Metabolism in Hyperlipidemic C57BL/6 Mice

Integrated Metagenomics and Metabolomics to Reveal the Effects of Policosanol on Modulating the Gut Microbiota and Lipid Metabolism in Hyperlipidemic C57BL/6 Mice

The aim of the study was to investigate the regulatory effects of policosanol on hyperlipidemia, gut microbiota and metabolic status in a C57BL/6 mouse model. A total of 35 C57BL/6 mice were assigned to 3 groups, chow (n=12), high fat diet (HFD, n=12) and HFD+policosanol (n=11), then treated for 18...

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Bibliographic Details
Main Authors: Zhenya Zhai, Jianping Liu, Kai-Min Niu, Chong Lin, Yue Tu, Yichun Liu, Lichuang Cai, Huiping Liu, Kexian Ouyang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Endocrinology
Subjects:
policosanol
gut microbiota
metabolomics
C57BL/6 mouse
antihyperlipidemia
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.722055/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.722055/full

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