Mechanism of Deletion Removing All Dystrophin Exons in a Canine Model for DMD Implicates Concerted Evolution of X Chromosome Pseudogenes

Mechanism of Deletion Removing All Dystrophin Exons in a Canine Model for DMD Implicates Concerted Evolution of X Chromosome Pseudogenes

Duchenne muscular dystrophy (DMD) is a lethal, X-linked, muscle-wasting disorder caused by mutations in the large, 2.4-Mb dystrophin gene. The majority of DMD-causing mutations are sporadic, multi-exon, frameshifting deletions, with the potential for variable immunological tolerance to the dystrophi...

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Bibliographic Details
Main Authors: D. Jake VanBelzen, Alock S. Malik, Paula S. Henthorn, Joe N. Kornegay, Hansell H. Stedman
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Duchenne muscular dystrophy
concerted evolution
pseudogene
dystrophin-null
German shorthaired pointer
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301346

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http://www.sciencedirect.com/science/article/pii/S2329050116301346

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