Balancing selection at a premature stop mutation in the myostatin gene underlies a recessive leg weakness syndrome in pigs.

Balancing selection at a premature stop mutation in the myostatin gene underlies a recessive leg weakness syndrome in pigs.

Balancing selection provides a plausible explanation for the maintenance of deleterious alleles at moderate frequency in livestock, including lethal recessives exhibiting heterozygous advantage in carriers. In the current study, a leg weakness syndrome causing mortality of piglets in a commercial li...

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Bibliographic Details
Main Authors: Oswald Matika, Diego Robledo, Ricardo Pong-Wong, Stephen C Bishop, Valentina Riggio, Heather Finlayson, Natalie R Lowe, Annabelle E Hoste, Grant A Walling, Jorge Del-Pozo, Alan L Archibald, John A Woolliams, Ross D Houston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6370237?pdf=render

Internet

http://europepmc.org/articles/PMC6370237?pdf=render

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