Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly revers...

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Bibliographic Details
Main Authors: Hitomi Higuchi, Shota Yamamoto, Soichiro Ushio, Takehiro Kawashiri, Nobuaki Egashira
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Goshajinkigan
Bortezomib
Peripheral neuropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002030

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http://www.sciencedirect.com/science/article/pii/S1347861315002030

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