IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro

IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro

Background/Aims: Evidence suggests that IL-6 affects bone mass by modulating osteocyte communication towards osteoclasts. However, the mechanism by which IL-6 enhances osteocyte-mediated osteoclastogenesis is unclear. We aimed to investigate the inflammatory factors in serum after orthodontic surger...

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Bibliographic Details
Main Authors: Qing Wu, Xiaokang Zhou, Danqing Huang, Yingchen JI, Feiwu Kang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Surgery first
Interleukin-6
IL-6 receptor
Osteocyte
Receptor activator of nuclear factor-κB ligand
AG490
Janus kinase
Signal transducer and activator of transcription
Osteoclastogenesis
Online Access:http://www.karger.com/Article/FullText/465455

Internet

http://www.karger.com/Article/FullText/465455

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