Depletion of Ascorbic Acid Restricts Angiogenesis and Retards Tumor Growth in a Mouse Model

Depletion of Ascorbic Acid Restricts Angiogenesis and Retards Tumor Growth in a Mouse Model

Angiogenesis requires the deposition of type IV collagen by endothelial cells into the basement membrane of new blood vessels. Stabilization of type IV collagen triple helix depends on the hydroxylation of proline, which is catalyzed by the iron-containing enzyme prolyl hydroxylase. This enzyme, in...

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Bibliographic Details
Main Authors: Sucheta Telang, Amy L. Clem, John W. Eaton, Jason Chesney
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Ascorbic acid
tumor
angiogenesis
collagen
prolyl hydroxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800145

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http://www.sciencedirect.com/science/article/pii/S1476558607800145

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