Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model.

Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model.

Chondroitin sulfate E (CS-E), a highly sulfated glycosaminoglycan, is known to promote tumor invasion and metastasis. Because the presence of CS-E is detected in both tumor and stromal cells in pancreatic ductal adenocarcinoma (PDAC), multistage involvement of CS-E in the development of PDAC has bee...

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Bibliographic Details
Main Authors: Kazuki Takakura, Yuichiro Shibazaki, Hiroyuki Yoneyama, Masato Fujii, Taishi Hashiguchi, Zensho Ito, Mikio Kajihara, Takeyuki Misawa, Sadamu Homma, Toshifumi Ohkusa, Shigeo Koido
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4671730?pdf=render

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http://europepmc.org/articles/PMC4671730?pdf=render

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