Deciphering hierarchical organization of topologically associated domains through change-point testing

Deciphering hierarchical organization of topologically associated domains through change-point testing

Abstract Background The nucleus of eukaryotic cells spatially packages chromosomes into a hierarchical and distinct segregation that plays critical roles in maintaining transcription regulation. High-throughput methods of chromosome conformation capture, such as Hi-C, have revealed topologically ass...

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Bibliographic Details
Main Authors: Haipeng Xing, Yingru Wu, Michael Q. Zhang, Yong Chen
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Bioinformatics
Subjects:
Hi-C data
Chromatin interaction
Hierarchical TADs
Change-points
Generalized likelihood-ratio test
Online Access:https://doi.org/10.1186/s12859-021-04113-8

Internet

https://doi.org/10.1186/s12859-021-04113-8

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