Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation

<p>Abstract</p> <p>Background</p> <p>The Wnt/β-catenin pathway is a major signaling cascade in bone biology, playing a key role in bone development and remodeling. The objectives of this study were firstly, to determine the effects of dexamethasone exposure on Wnt/β-cat...

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Bibliographic Details
Main Authors: Butler Joseph S, Queally Joseph M, Devitt Brian M, Murray David W, Doran Peter P, O'Byrne John M
Format: Article
Language:English
Published: BMC 2010-09-01
Series:BMC Musculoskeletal Disorders
Online Access:http://www.biomedcentral.com/1471-2474/11/210