PPIs Are Not Responsible for Elevating Cardiovascular Risk in Patients on Clopidogrel—A Systematic Review and Meta-Analysis

PPIs Are Not Responsible for Elevating Cardiovascular Risk in Patients on Clopidogrel—A Systematic Review and Meta-Analysis

Background: Clopidogrel and proton pump inhibitors (PPIs) are metabolized by cytochrome P450 enzymes. Contradictory results have been reported on possible complications of simultaneous PPI and clopidogrel use. Our aim was to investigate the clinical relevance of this debate with a systematic review...

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Bibliographic Details
Main Authors: Alexandra Demcsák, Tamás Lantos, Emese Réka Bálint, Petra Hartmann, Áron Vincze, Judit Bajor, László Czopf, Hussain Alizadeh, Zoltán Gyöngyi, Katalin Márta, Alexandra Mikó, Zsolt Szakács, Dániel Pécsi, Péter Hegyi, Imre László Szabó
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Physiology
Subjects:
proton pump inhibitors
clopidogrel
cardiovascular risk
drug interaction
cytochrome P450
meta-analysis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01550/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01550/full

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