Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease.
BACKGROUND: Prion diseases are a group of invariably fatal neurodegenerative disorders affecting humans and a wide range of mammals. An essential part of the infectious agent, termed the prion, is composed of an abnormal isoform (PrPSc) of a host-encoded normal cellular protein (PrPC). The conversio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-02-01
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| Series: | PLoS Medicine |
| Online Access: | http://europepmc.org/articles/PMC1316067?pdf=render |