<it>Arx </it>and <it>Nkx2.2 </it>compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a <it>somatostatin</it>/<it>ghrelin </it>co-expressing cell lineage
<p>Abstract</p> <p>Background</p> <p>Nkx2.2 and Arx represent key transcription factors implicated in the specification of islet cell subtypes during pancreas development. Mice deficient for <it>Arx </it>do not develop any alpha-cells whereas beta- and delta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-08-01
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| Series: | BMC Developmental Biology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-213X/11/52 |