IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis

IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis

Abstract Background Age-related macular degeneration is characterized by the accumulation of subretinal macrophages and the degeneration of cones, but mainly of rods. We have previously shown that Mononuclear Phagocytes-derived IL-1β induces rod photoreceptor cell death during experimental subretina...

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Bibliographic Details
Main Authors: Hugo Charles-Messance, Guillaume Blot, Aude Couturier, Lucile Vignaud, Sara Touhami, Fanny Beguier, Lourdes Siqueiros, Valérie Forster, Nour Barmo, Sébastien Augustin, Serge Picaud, José-Alain Sahel, Alvaro Rendon, Antje Grosche, Ramin Tadayoni, Florian Sennlaub, Xavier Guillonneau
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Age-related macular degeneration
Monocyte
Macrophage
Photoreceptor
Glutamate
Online Access:https://doi.org/10.1186/s12974-019-1655-5

Internet

https://doi.org/10.1186/s12974-019-1655-5

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